Test ID LBOR0150 TPMT Genotyping
AKA
Azathioprine, Mercaptopurine, Thioguanine
Additional Information
See Thiopurine S-Methyltransferase (TPMT) Genotyping for additional information.
Specimen Type/Requirements
Lavender top (EDTA) tube - Whole Blood
Blood samples will not be accepted for patients that have undergone an allogenic transplant (e.g. bone marrow or peripheral stem cell) OR that have a history of chronic lymphocytic leukemia (CLL).
Transfusion patients: Wait at least 2 weeks after a packed cell/platelet transfusion, and at least 4 weeks after a whole blood transfusion prior to blood draw for testing.
Chemotherapy patients: DNA quality may be affected if patient has received chemotherapy within the last 120 days. Clients will be contacted to provide additional specimen if DNA quality is insufficient.
All specimens should be sent in original container and should not be aliquoted to another tube.
In addition, the specimen submitted should ONLY be used for this testing and should not be shared with any other testing that would utilize this specimen type.
Test is not affected by hemolysis or lipemia.
Stability/Transport
Room Temperature | 72 hours | |
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Refrigerated | 7 days | Preferred for transport |
Frozen | Not Acceptable |
Performed Test Frequency
Monday through Friday
Methodology
Allele-specific PCR
Performing Lab
Sanford Laboratories Sioux Falls
CPT
81335
Specimen Volume
Preferred Volume | 2.0 - 4.0 mL |
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Minimum Volume | 1.0 mL |
Report Available
5 – 7 days
Useful For
- Identify patients who are at risk for abnormal drug metabolism and toxicity from thiopurine drugs metabolized by thiopurine-S-methyltransferase (TPMT), including but not limited to azathioprine, 6-mercaptopurine, and 6 – thioguanine.
- Identify genotypes shown to have a drug-gene variant.