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Test ID LBOR0170 Chromosomal Microarray, Hematologic Disorders, Varies

Useful For

Detection and characterization of clonal copy number imbalance and loss of heterozygosity associated with hematologic neoplasms

 

Assisting in the diagnosis and classification of certain hematologic neoplasms

 

Evaluating the prognosis for patients with certain hematologic neoplasms

Specimen Type

Varies


Ordering Guidance


This test is not appropriate for detecting constitutional/congenital copy number changes or regions of excessive homozygosity. If this test is ordered with a reason for testing indicating a constitutional/congenital disorder, the test will be canceled and CMACB / Chromosomal Microarray, Congenital, Blood will be added and performed as the appropriate test.



Shipping Instructions


Advise Express Mail or equivalent if not on courier service.



Necessary Information


1. A reason for testing must be provided for testing to be performed.

2. A pathology report should accompany the specimen. If this information is not available at the time of order, submit as soon as possible for appropriateness of testing and to aid in interpretation of results.



Specimen Required


Submit only 1 of the following specimens:

 

Specimen Type: Bone marrow

Container/Tube:

Preferred: Green top (sodium heparin)

Acceptable: Lavender top (EDTA)

Specimen Volume: 1-2 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Send bone marrow specimen in original tube. Do not aliquot.

 

Specimen Type: Whole blood

Container/Tube:

Preferred: Green top (sodium heparin)

Acceptable: Lavender top (EDTA)

Specimen Volume: 7-10 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send whole blood specimen in original tube. Do not aliquot.


Specimen Minimum Volume

Blood: 2 mL; Bone marrow: 1 mL

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
  Refrigerated 

Day(s) Performed

Monday through Sunday

Report Available

7 to 14 days

Method Name

Chromosomal Microarray (CMA)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

81277

Testing Algorithm

DNA extraction is always performed on the specimen prior to hybridization to the microarray. An unstimulated cell culture will be set up on all specimens with adequate volume and held pending additional testing. If additional testing is requested, such as karyotype analysis or fluorescence in situ hybridization, it will be performed at an additional charge.

 

The following algorithms are available:

-Aggressive B-cell Lymphoma Diagnostic Algorithm

-B-Lymphoblastic Leukemia/Lymphoma Algorithm

Reporting Name

Chromosomal Microarray, Hematologic

Reference Values

An interpretive report will be provided.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Secondary ID

35899

Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen. 

Sanford Laboratories - Fargo Additional Information:

SANFORD INTERFACE BUILD INFORMATION

Result Code Result Code Description
21722 Result Summary
21723 Result
21724 Nomenclature
21725 Interpretation
21726 Reason for Referral
21727 Specimen
21728 Source
21729 Method
21730 Additional Information
21731 Released By