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HelpTest ID BLOD1230 Alpha-1-Antitrypsin Proteotype S/Z, LC-MS/MS, Serum
Useful For
Identification of homozygous and heterozygous S and Z proteotypes of alpha-1-antitrypsin deficiency
Specimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1.25 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Day(s) Performed
Monday, Thursday
Report Available
7 to 14 daysMethod Name
A1ASZ: Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
AATP: Nephelometry
A1APR: Isoelectric Focusing
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82103
82542
82104 (if appropriate)
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| A1ASZ | A1AT Proteotype S/Z, LC-MS/MS | No | Yes |
| AATP | Alpha-1-Antitrypsin, S | Yes, (order AAT) | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| A1APR | Alpha-1-Antitrypsin Phenotype, S | Yes, (order A1APP) | No |
Testing Algorithm
If the mass spectrometry proteotype and quantitative serum level are discordant, then phenotyping will be added and performed at an additional charge.
For more information see Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm
Special Instructions
Reporting Name
A1AT Proteotype S/Z, LC-MS/MS, SReference Values
ALPHA-1-ANTITRYPSIN:
100-190 mg/dL
ALPHA-1-ANTITRYPSIN PROTEOTYPE:
Negative for S and Z phenotype (Non S Non Z)
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Forms
If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request (T728) with the specimen.
SANFORD INTERFACE BUILD INFORMATION
| Result Code | Result Code Description |
|---|---|
| 19282 | A1AT Proteotype S/Z, LC-MS/MS |
| 16140 | Alpha-1-Antitrypsin, S |