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Test ID BLOD1061 Islet Antigen 2 (IA-2) Antibody, Serum

Useful For

Clinical distinction of type 1 from type 2 diabetes mellitus

 

Identification of individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes)

 

Prediction of future need for insulin treatment in adult-onset diabetic patients

Specimen Type

Serum


Ordering Guidance


Islet cell antigen 2 (IA2) testing is available individually (this test) and with glutamic acid decarboxylase 65-kilodalton isoform (GAD65), insulin, and zinc transporter 8 (ZnT8) antibodies as a part of DBS1 / Diabetes Mellitus Type 1 Evaluation, Serum. The evaluation is most appropriate to order in the following clinical contexts:

-Distinguishing type 1 (autoimmune) diabetes mellitus from type 2 diabetes mellitus

-Identifying individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes) 

-Predicting future insulin requirement treatment in patients with adult-onset diabetes

 

Individual antibody testing would be more appropriate if 1, 2, or 3 of the analytes (GAD65, IA-2, insulin, ZnT8 antibodies) have already been tested and reported negative, and the provider wishes to test for the balance of remaining untested analytes only.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

1 mL

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Day(s) Performed

Monday through Friday

Report Available

3 to 9 days

Method Name

Radioimmunoassay (RIA)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86341

Reporting Name

IA-2 Ab, S

Reference Values

≤0.02 nmol/L

Reference values apply to all ages.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Secondary ID

89588
Sanford Laboratories - Fargo Additional Information:

SANFORD INTERFACE BUILD INFORMATION

Result Code Result Code Description
17064 IA-2 AB, S