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Test ID BLOD0397 Carbamazepine-10,11-Epoxide, Serum

Useful For

Monitoring patients exhibiting symptoms of carbamazepine toxicity whose total serum carbamazepine concentration is within the therapeutic range, but who may be producing significant levels of the active metabolite epoxide, which can accumulate to concentrations equivalent to carbamazepine

Specimen Type

Serum Red

Specimen Required

Container/Tube: Red top

Specimen Volume: 2 mL

Collection Instructions: Draw blood 12 hours (trough value) after last dose.

Specimen Minimum Volume

1 mL

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK; Gross reject


Whole blood, plasma, or serum gel tube

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 7 days
  Frozen  28 days
  Ambient  48 hours

Day(s) and Time(s) Performed

CARTA: Monday through Sunday; Continuously

1011E: Tuesday; 11 a.m.

Analytic Time

Same day/1 day

Method Name

CARTA: Homogeneous Microparticle Agglutination Immunoassay

1011E: High-Performance Liquid Chromatography (HPLC)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

80156-Carbamazepine, Tot, S


Profile Information

Test ID Reporting Name Available Separately Always Performed
CARTA Carbamazepine, Tot, S Yes Yes
1011E Carb-10,11-Epoxide, S No Yes

Reporting Name

Carbamazepine-10,11-Epoxide, S

Reference Values


Therapeutic: 4.0-12.0 mcg/mL

Critical value: ≥15.0 mcg/mL



Therapeutic concentration: 0.4-4.0 mcg/mL

Toxic concentration: ≥8.0 mcg/mL

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
Sanford Laboratories - Fargo Additional Information:


Result Code Result Code Description
17859 Carbemazepine, Total, S
801 Carbamazepine Epoxide