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Test ID NBLD0356 NTX-Telopeptide, Urine

Secondary ID


Useful For

As an adjunct in the diagnosis of medical conditions associated with increased bone turnover


Monitoring effectiveness of antiresorptive therapy in patients treated for osteopenia, osteoporosis, Paget disease, or other metabolic bone disorders

Profile Information

Test ID Reporting Name Available Separately Always Performed
NTXCT Creatinine, U No Yes
NTXUR NTX-Telopeptide, U No Yes

Method Name

NTXUR: VITROS Competitive Chemiluminescence Immunoassay

NTXCT: Enzymatic Colorimetric Assay

Reporting Name

NTX-Telopeptide, U

Specimen Type


Specimen Required

Patient Preparation: For 24 hours before this urine collection, do not take multivitamins or dietary supplements containing biotin or vitamin B7 that are commonly found in hair, skin, and nail supplements and multivitamins.

Container/Tube: Plastic, 13-mL urine tube

Specimen Volume: 4 mL

Collection Instructions:

1. Collect second morning void.

2. No preservative.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen (preferred) 30 days
  Refrigerated  14 days
  Ambient  72 hours

Reject Due To


Mild reject; Gross reject






Specimen with pH <5; specimen containing preservatives

Reference Values

All units are reported in nmol Bone Collagen Equivalents/mmol creatinine.

Adult (≥18 years of age)


21-83 nmol BCE/mmol creatinine



Premenopausal: 17-94 nmol BCE/mmol creatinine

Postmenopausal: 26-124 nmol BCE/mmol creatinine




Tanner Stage I: 55-508 nmol BCE/mmol creatinine

Tanner Stage II: 21-423 nmol BCE/mmol creatinine

Tanner Stage III: 27-462 nmol BCE/mmol creatinine

Tanner Stage IV: <609 nmol BCE/mmol creatinine

Tanner Stage V: <240 nmol BCE/mmol creatinine



Tanner Stage I: 6-662 nmol BCE/mmol creatinine

Tanner Stage II: 193-514 nmol BCE/mmol creatinine

Tanner Stage III: 13-632 nmol BCE/mmol creatinine

Tanner Stage IV: <389 nmol BCE/mmol creatinine

Tanner Stage V: <132 nmol BCE/mmol creatinine

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; Varies

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
NTXPR NTX-Telopeptide, U In Process


Result ID Test Result Name Result LOINC Value
NTXCT Creatinine, U 2161-8
NTX NTX 35334-2
NTXCR NTX-Telopeptide, U 14115-0


If not ordering electronically, complete, print, and send a General Request Form (T239) with the specimen (